Biochemical analysis of TOPBP1 oligomerization
نویسندگان
چکیده
منابع مشابه
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.
Regulation of E2F1-mediated apoptosis is essential for proper cellular growth. This control requires TopBP1, a BRCT (BRCA1 carboxyl-terminal) domain-containing protein, which interacts with E2F1 but not other E2Fs and represses its proapoptotic activity. We now show that the regulation of E2F1 by TopBP1 involves the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway, and is independent of p...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2020
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2020.102973